Monitoring Disopyramide, Lidocaine, and Quinidine by Micellar Liquid Chromatography
نویسندگان
چکیده
منابع مشابه
Simultaneous liquid-chromatographic determination of three antiarrhythmic drugs: disopyramide, lidocaine, and quinidine.
We report a common methodology for determining three antiarrhythmic drugs: disopyramide, lidocaine, and quinidine. Alkalinized serum and internal standard (p-chlorodisopyramide) are extracted into dichloromethane, the organic phase is evaporated, and the redissolved residue is injected onto a reversed-phase column (micron Bondapack C18). Quantitation is via peak-height ratios of analyte vs inte...
متن کاملDetermination of disopyramide in plasma by high-performance liquid chromatography.
Disopyramide [4-di-isopropylamino-2-phenyl2-(2-pyridyl)-butyramide] is frequently used in the suppression and prevention of cardiac arrhythmias [I]. Because of the relatively narrow therapeutic index and the intersubject variability in the pharmacokinetics of this drug, monitoring of its concentration in plasma may assist in individualizing the dosage requirements. Chromatographic methods have ...
متن کاملDisopyramide determination by gas chromatography, liquid chromatography, and gas chromatography--mass spectrometry.
Disopyramide is determined in serum by gas chromatography with a nitrogen-selective detector, by liquid chromatography, and by gas chromatography--mass spectrometry. Comparable results are obtained with the three techniques, with a within-run and between-run precision of 5 to 10% (coefficient of variation). Least-squares analysis of data on patients' sera, analyzed first by gas chromatography (...
متن کاملDetermination of quinidine by high-performance liquid chromatography.
Quinidine in serum was measured at 330 nm, after protein precipitation, with an alkyl phenyl reversed-phase chromatographic column by peak-height determination (external standards.) Sensitivity was 0.3 mg/liter, with linear response to at least 10 mg/liter serum. Interassay precision, measured on 20 consecutive days, gave a CV of 8.2% at 2 mg/liter of serum and 5.1% at 5 mg/liter. Quinine and p...
متن کاملSeparation of Sedative – Hypnotic Drugs with Mixed Micellar Liquid Chromatography
Separation of ten sedative- hypnotic drugs was performed by RP-HPLC using mixed micellar mobile phase. Effect of temperature, type and amount of organic modifier in mobile phase on efficiency (N) and asymmetry factor (B/A) showed that, the appropriate conditions for a good separation were 35°C and 7% (V/V) butanol in mobile phase. Variations of selectivity factor versus butanol concent...
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ژورنال
عنوان ژورنال: Journal of AOAC INTERNATIONAL
سال: 2011
ISSN: 1060-3271,1944-7922
DOI: 10.1093/jaoac/94.2.537